A fatal crash closed all eastbound express lanes along a stretch of Highway 401 in Mississauga on Tuesday morning.
The collision between a transport truck and an SUV happened shortly after 4 a.m. just east of Dixie Road, Ontario Provincial Police said.
Early reports suggest the driver of the SUV slammed into the rear of the truck.
A female passenger inside the SUV was pronounced dead at the scene, according to OPP, while the male driver had critical injuries.
The eastbound express lanes are closed to traffic from Mississauga Road. There is also no access to the express lanes from Highway 403.
Provincial police expect the closure to last throughout the morning.
Drivers were advised to consider alternate routes while police investigate.